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Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study

The optimum treatment for high-risk soft-tissue sarcoma (STS) in adults is unclear. Regional hyperthermia concentrates the action of chemotherapy within the heated tumour region. Phase 2 studies have shown that chemotherapy with regional hyperthermia improves local control compared with chemotherapy alone. We designed a parallel-group randomised controlled trial to assess the safety and efficacy of […]

Multi-targeted prevention of cancer by sulforaphane

Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage. Epidemiologic studies suggest that cruciferous vegetable intake may lower overall cancer risk, including colon and prostate cancer. Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables and is especially high in broccoli and broccoli sprouts. SFN has proved to be an […]

Results in brain tumors with locoregional RF hyperthermia in the GIMT

In contrast to the enormous therapeutic efforts, the results of conventional treatments for highly malignant brain tumors (gliomas) are rather unsatisfactory. The prognosis for this tumor type is poor, its median overall survival (6-14 months) is less than one year (1,2,5,6,8). Most of the cases are inoperable, or only partial removal is possible, and the […]

Effective Natural Remedies in Complementary Oncology

Naturopathic antineoplastic agent “artesunate” (Artemisia annua – mugwort) acts as a biological apoptosis inducer and potential anti-cancer drug. In the field of holistic, complementary cancer treatment wins the made of leaves and flowers of the one-year-old mugwort (Artemisia annua) obtained natural active ingredient artesunate an increasingly larger and important therapeutic value.

Differences in heat sensitivity between normal and acute myeloid leukemic stem cells: feasibility of hyperthermic purging of leukemic cells from autologous stem cell grafts

In autologous stem cell transplantation contamination of the graft with malignant cells is frequently noticed and necessitates the use of in vivo or in vitro purging modalities. The hematopoietic recovery after transplantation depends on the number of stem and progenitor cells in the transplant. Therefore, in the present study the effects of hyperthermic treatment on […]