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Hyperthermie: ein potenter Verstärker der Strahlentherapie
March 9, 2019 in Hyperthermie /by administratorHyperthermie: een krachtige versterker van radiotherapie
March 9, 2019 in Hyperthermie /by administratorHyperthermia: a Potent Enhancer of Radiotherapy
March 9, 2019 in Hyperthermia /by administratorVegetable and fruit intake after diagnosis and risk of prostate cancer progression
March 7, 2019 in Diet and Excerise, Raphan /by administratorCruciferous vegetables, tomato sauce and legumes have been associated with reduced risk of incident advanced prostate cancer. In vitro and animal studies suggest these foods may inhibit progression of prostate cancer, but there are limited data in men. Therefore, we prospectively examined whether intake of total vegetables, and specifically cruciferous vegetables, tomato sauce and legumes, […]
Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
March 7, 2019 in Diet and Excerise, Raphan /by administratorThe existence of cancer stem cells (CSCs) in breast cancer has profound implications for cancer prevention. In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism. Sulforaphane inhibits breast CSCs and downregulates the Wnt/beta-catenin self-renewal pathway. These findings support the use of […]
Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate
March 7, 2019 in Diet and Excerise, Raphan /by administrator2018-09-22Despite intense efforts to develop treatments against pancreatic cancer, agents that cure this highly resistant and metastasizing disease are not available. Considerable attention has focused on broccoli compound sulforaphane (SF), which is suggested as combination therapy for targeting of pancreatic cancer stem cells (CSCs). However, there are concerns that antioxidative properties of SF may interfere […]
Sulforaphane and related mustard oils in focus of cancer prevention and therapy
March 7, 2019 in Diet and Excerise, Raphan /by administratorThe plant family Brassicaceae, formerly Cruciferae, contains mustard oil glycosides, from which mustard oils are enzymatically hydrolyzed. Mustard oils offer protection from pests, microorganisms and fungi. More than 120 different mustard oils with various biological functions are known. Since ancient times, these substances are used as natural antibiotics, antiviral drugs and antimycotics. The antioxidative effect […]
Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
March 7, 2019 in Diet and Excerise, Raphan /by administratorBroccoli sprouts are widely consumed in many parts of the world. There have been no reported concerns with respect to their tolerance and safety in humans. A formal phase I study of safety, tolerance, and pharmacokinetics appeared justified because these sprouts are being used as vehicles for the delivery of the glucosinolate glucoraphanin and its […]
Reveratrol after Dr. Sass
March 7, 2019 in Resveratrol /by administratorResveratrol is known to science because of its numerous positive pharmacological effects and not least because of the “French paradox” (Nancy-study). This describes the fact that the French, in spite of high consumption of saturated fatty acids and nicotine, have a much lower rate (< 40 %) of cardiovascular disease through the regular consumption of […]
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